International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19.
Identifieur interne : 000C59 ( Main/Exploration ); précédent : 000C58; suivant : 000C60International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19.
Auteurs : Verena Börger [Allemagne] ; Daniel J. Weiss [États-Unis] ; Johnathon D. Anderson [États-Unis] ; Francesc E. Borràs [Espagne] ; Benedetta Bussolati [Italie] ; David R F. Carter [Royaume-Uni] ; Massimo Dominici [Italie] ; Juan M. Falc N-Pérez [Espagne] ; Mario Gimona [Autriche] ; Andrew F. Hill [Australie] ; Andrew M. Hoffman [États-Unis] ; Dominique De Kleijn [Pays-Bas] ; Bruce L. Levine [États-Unis] ; Rebecca Lim [Australie] ; Jan Lötvall [Suède] ; S Alex Mitsialis [États-Unis] ; Marta Mongui Tortajada [Espagne] ; Maurizio Muraca [Italie] ; Rienk Nieuwland [Pays-Bas] ; Anna Nowocin [Royaume-Uni] ; Lorraine O'Driscoll [Irlande (pays)] ; Luis A. Ortiz [États-Unis] ; Donald G. Phinney [États-Unis] ; Ilona Reischl [Autriche] ; Eva Rohde [Autriche] ; Ralf Sanzenbacher [Allemagne] ; Clotilde Théry [France] ; Wei Seong Toh [Singapour] ; Kenneth W. Witwer [États-Unis] ; Sai Kiang Lim [Singapour] ; Bernd Giebel [Allemagne]Source :
- Cytotherapy [ 1477-2566 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- cytologie : Cellules souches mésenchymateuses.
- immunologie : Infections à coronavirus.
- traitement médicamenteux : Infections à coronavirus.
- transplantation : Exosomes, Humains, Sociétés savantes, Vésicules extracellulaires.
English descriptors
- KwdEn :
- MESH :
- cytology : Mesenchymal Stem Cells.
- drug therapy : Coronavirus Infections.
- immunology : Coronavirus Infections.
- transplantation : Exosomes, Extracellular Vesicles.
- Humans, Societies, Scientific.
Abstract
STATEMENT
The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles (EVs, including exosomes) from mesenchymal stromal cells (MSCs) and possibly other cell sources as treatments for COVID-19. Research and trials in this area are encouraged. However, ISEV and ISCT do not currently endorse the use of EVs or exosomes for any purpose in COVID-19, including but not limited to reducing cytokine storm, exerting regenerative effects or delivering drugs, pending the generation of appropriate manufacturing and quality control provisions, pre-clinical safety and efficacy data, rational clinical trial design and proper regulatory oversight.
DOI: 10.1016/j.jcyt.2020.05.002
PubMed: 32425691
PubMed Central: PMC7229942
Affiliations:
- Allemagne, Australie, Autriche, Espagne, France, Irlande (pays), Italie, Pays-Bas, Royaume-Uni, Singapour, Suède, États-Unis
- Angleterre, Californie, Floride, Hollande-Septentrionale, Maryland, Massachusetts, Oxfordshire, Pennsylvanie, Piémont, Utrecht (province), Vermont, Victoria (État), Vienne (Autriche), Île-de-France
- Amsterdam, Melbourne, Oxford, Paris, Pittsburgh, Turin, Utrecht, Vienne (Autriche)
- Université d'Amsterdam, Université de Pittsburgh, Université nationale de Singapour
Links toward previous steps (curation, corpus...)
Le document en format XML
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Carter</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biological and Medical Sciences, Oxford Brookes University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Dominici, Massimo" sort="Dominici, Massimo" uniqKey="Dominici M" first="Massimo" last="Dominici">Massimo Dominici</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical and Surgical Sciences of Children and Adults, University Hospital of Modena, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences of Children and Adults, University Hospital of Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Falc N Perez, Juan M" sort="Falc N Perez, Juan M" uniqKey="Falc N Perez J" first="Juan M" last="Falc N-Pérez">Juan M. Falc N-Pérez</name><affiliation wicri:level="1"><nlm:affiliation>Exosomes Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain; Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Exosomes Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain; Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao</wicri:regionArea><wicri:noRegion>Bilbao</wicri:noRegion></affiliation></author><author><name sortKey="Gimona, Mario" sort="Gimona, Mario" uniqKey="Gimona M" first="Mario" last="Gimona">Mario Gimona</name><affiliation wicri:level="1"><nlm:affiliation>GMP Unit and EV-TT Transfer Center, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>GMP Unit and EV-TT Transfer Center, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Andrew F" sort="Hill, Andrew F" uniqKey="Hill A" first="Andrew F" last="Hill">Andrew F. Hill</name><affiliation wicri:level="1"><nlm:affiliation>La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>La Trobe Institute for Molecular Science, La Trobe University, Bundoora</wicri:regionArea><wicri:noRegion>Bundoora</wicri:noRegion></affiliation></author><author><name sortKey="Hoffman, Andrew M" sort="Hoffman, Andrew M" uniqKey="Hoffman A" first="Andrew M" last="Hoffman">Andrew M. Hoffman</name><affiliation wicri:level="2"><nlm:affiliation>School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="De Kleijn, Dominique" sort="De Kleijn, Dominique" uniqKey="De Kleijn D" first="Dominique" last="De Kleijn">Dominique De Kleijn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Surgery, University Medical Center Utrecht and Netherlands Heart Institute, Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Vascular Surgery, University Medical Center Utrecht and Netherlands Heart Institute, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Levine, Bruce L" sort="Levine, Bruce L" uniqKey="Levine B" first="Bruce L" last="Levine">Bruce L. Levine</name><affiliation wicri:level="2"><nlm:affiliation>Center for Cellular Immunotherapies at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Cellular Immunotherapies at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lim, Rebecca" sort="Lim, Rebecca" uniqKey="Lim R" first="Rebecca" last="Lim">Rebecca Lim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Obstetrics and Gynaecology, Hudson Institute of Medical Research, Monash University and The Ritchie Centre, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Hudson Institute of Medical Research, Monash University and The Ritchie Centre, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Lotvall, Jan" sort="Lotvall, Jan" uniqKey="Lotvall J" first="Jan" last="Lötvall">Jan Lötvall</name><affiliation wicri:level="1"><nlm:affiliation>Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Mitsialis, S Alex" sort="Mitsialis, S Alex" uniqKey="Mitsialis S" first="S Alex" last="Mitsialis">S Alex Mitsialis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Harvard Medical School and Boston Children's Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Harvard Medical School and Boston Children's Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mongui Tortajada, Marta" sort="Mongui Tortajada, Marta" uniqKey="Mongui Tortajada M" first="Marta" last="Mongui Tortajada">Marta Mongui Tortajada</name><affiliation wicri:level="1"><nlm:affiliation>ICREC Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, and Cardiology Service, Germans Trias i Pujol University Hospital, Badalona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>ICREC Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, and Cardiology Service, Germans Trias i Pujol University Hospital, Badalona</wicri:regionArea><wicri:noRegion>Badalona</wicri:noRegion></affiliation></author><author><name sortKey="Muraca, Maurizio" sort="Muraca, Maurizio" uniqKey="Muraca M" first="Maurizio" last="Muraca">Maurizio Muraca</name><affiliation wicri:level="1"><nlm:affiliation>Department of Women's and Children's Health, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Women's and Children's Health, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Nieuwland, Rienk" sort="Nieuwland, Rienk" uniqKey="Nieuwland R" first="Rienk" last="Nieuwland">Rienk Nieuwland</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Experimental Clinical Chemistry, Department of Clinical Chemistry and Vesicle Observation Center, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Laboratory of Experimental Clinical Chemistry, Department of Clinical Chemistry and Vesicle Observation Center, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Nowocin, Anna" sort="Nowocin, Anna" uniqKey="Nowocin A" first="Anna" last="Nowocin">Anna Nowocin</name><affiliation wicri:level="1"><nlm:affiliation>Biotherapeutics, National Institute for Biological Standards and Control (NIBSC), Medicines and Healthcare Products Regulatory Agency, Hertfordshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Biotherapeutics, National Institute for Biological Standards and Control (NIBSC), Medicines and Healthcare Products Regulatory Agency, Hertfordshire</wicri:regionArea><wicri:noRegion>Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="O Driscoll, Lorraine" sort="O Driscoll, Lorraine" uniqKey="O Driscoll L" first="Lorraine" last="O'Driscoll">Lorraine O'Driscoll</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Ortiz, Luis A" sort="Ortiz, Luis A" uniqKey="Ortiz L" first="Luis A" last="Ortiz">Luis A. Ortiz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Phinney, Donald G" sort="Phinney, Donald G" uniqKey="Phinney D" first="Donald G" last="Phinney">Donald G. Phinney</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Reischl, Ilona" sort="Reischl, Ilona" uniqKey="Reischl I" first="Ilona" last="Reischl">Ilona Reischl</name><affiliation wicri:level="3"><nlm:affiliation>Federal Office for Safety in Health Care (BASG) and Austrian Agency for Health and Food Safety (AGES), Institute Surveillance, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Federal Office for Safety in Health Care (BASG) and Austrian Agency for Health and Food Safety (AGES), Institute Surveillance, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Rohde, Eva" sort="Rohde, Eva" uniqKey="Rohde E" first="Eva" last="Rohde">Eva Rohde</name><affiliation wicri:level="1"><nlm:affiliation>Department of Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria; GMP Unit, Spinal Cord Injury & Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria; GMP Unit, Spinal Cord Injury & Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Sanzenbacher, Ralf" sort="Sanzenbacher, Ralf" uniqKey="Sanzenbacher R" first="Ralf" last="Sanzenbacher">Ralf Sanzenbacher</name><affiliation wicri:level="1"><nlm:affiliation>Section Tissue Engineering and Cell Therapeutics, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section Tissue Engineering and Cell Therapeutics, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen</wicri:regionArea><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion></affiliation></author><author><name sortKey="Thery, Clotilde" sort="Thery, Clotilde" uniqKey="Thery C" first="Clotilde" last="Théry">Clotilde Théry</name><affiliation wicri:level="3"><nlm:affiliation>Institut Curie/INSERM U932/PSL Research University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie/INSERM U932/PSL Research University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Toh, Wei Seong" sort="Toh, Wei Seong" uniqKey="Toh W" first="Wei Seong" last="Toh">Wei Seong Toh</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Dentistry, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Faculty of Dentistry, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Witwer, Kenneth W" sort="Witwer, Kenneth W" uniqKey="Witwer K" first="Kenneth W" last="Witwer">Kenneth W. Witwer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: kwitwer1@jhmi.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lim, Sai Kiang" sort="Lim, Sai Kiang" uniqKey="Lim S" first="Sai Kiang" last="Lim">Sai Kiang Lim</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore. Electronic address: Lim_Sai_Kiang@imcb.a-star.edu.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research</wicri:regionArea><wicri:noRegion>Technology and Research</wicri:noRegion></affiliation></author><author><name sortKey="Giebel, Bernd" sort="Giebel, Bernd" uniqKey="Giebel B" first="Bernd" last="Giebel">Bernd Giebel</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address: bernd.giebel@uk-essen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32425691</idno><idno type="pmid">32425691</idno><idno type="doi">10.1016/j.jcyt.2020.05.002</idno><idno type="pmc">PMC7229942</idno><idno type="wicri:Area/Main/Corpus">001213</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001213</idno><idno type="wicri:Area/Main/Curation">001213</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001213</idno><idno type="wicri:Area/Main/Exploration">001213</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19.</title><author><name sortKey="Borger, Verena" sort="Borger, Verena" uniqKey="Borger V" first="Verena" last="Börger">Verena Börger</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Weiss, Daniel J" sort="Weiss, Daniel J" uniqKey="Weiss D" first="Daniel J" last="Weiss">Daniel J. Weiss</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Vermont, Burlington, Vermont, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Vermont, Burlington, Vermont</wicri:regionArea><placeName><region type="state">Vermont</region></placeName></affiliation></author><author><name sortKey="Anderson, Johnathon D" sort="Anderson, Johnathon D" uniqKey="Anderson J" first="Johnathon D" last="Anderson">Johnathon D. Anderson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology, Stem Cell Program, University of California, Davis, Davis, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology, Stem Cell Program, University of California, Davis, Davis, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Borras, Francesc E" sort="Borras, Francesc E" uniqKey="Borras F" first="Francesc E" last="Borràs">Francesc E. Borràs</name><affiliation wicri:level="1"><nlm:affiliation>REMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, and Nephrology Service, Germans Trias i Pujol University Hospital, Badalona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>REMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, and Nephrology Service, Germans Trias i Pujol University Hospital, Badalona</wicri:regionArea><wicri:noRegion>Badalona</wicri:noRegion></affiliation></author><author><name sortKey="Bussolati, Benedetta" sort="Bussolati, Benedetta" uniqKey="Bussolati B" first="Benedetta" last="Bussolati">Benedetta Bussolati</name><affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Carter, David R F" sort="Carter, David R F" uniqKey="Carter D" first="David R F" last="Carter">David R F. Carter</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biological and Medical Sciences, Oxford Brookes University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Dominici, Massimo" sort="Dominici, Massimo" uniqKey="Dominici M" first="Massimo" last="Dominici">Massimo Dominici</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical and Surgical Sciences of Children and Adults, University Hospital of Modena, Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical and Surgical Sciences of Children and Adults, University Hospital of Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Falc N Perez, Juan M" sort="Falc N Perez, Juan M" uniqKey="Falc N Perez J" first="Juan M" last="Falc N-Pérez">Juan M. Falc N-Pérez</name><affiliation wicri:level="1"><nlm:affiliation>Exosomes Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain; Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Exosomes Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain; Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao</wicri:regionArea><wicri:noRegion>Bilbao</wicri:noRegion></affiliation></author><author><name sortKey="Gimona, Mario" sort="Gimona, Mario" uniqKey="Gimona M" first="Mario" last="Gimona">Mario Gimona</name><affiliation wicri:level="1"><nlm:affiliation>GMP Unit and EV-TT Transfer Center, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>GMP Unit and EV-TT Transfer Center, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Andrew F" sort="Hill, Andrew F" uniqKey="Hill A" first="Andrew F" last="Hill">Andrew F. Hill</name><affiliation wicri:level="1"><nlm:affiliation>La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>La Trobe Institute for Molecular Science, La Trobe University, Bundoora</wicri:regionArea><wicri:noRegion>Bundoora</wicri:noRegion></affiliation></author><author><name sortKey="Hoffman, Andrew M" sort="Hoffman, Andrew M" uniqKey="Hoffman A" first="Andrew M" last="Hoffman">Andrew M. Hoffman</name><affiliation wicri:level="2"><nlm:affiliation>School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="De Kleijn, Dominique" sort="De Kleijn, Dominique" uniqKey="De Kleijn D" first="Dominique" last="De Kleijn">Dominique De Kleijn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Surgery, University Medical Center Utrecht and Netherlands Heart Institute, Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Vascular Surgery, University Medical Center Utrecht and Netherlands Heart Institute, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Levine, Bruce L" sort="Levine, Bruce L" uniqKey="Levine B" first="Bruce L" last="Levine">Bruce L. Levine</name><affiliation wicri:level="2"><nlm:affiliation>Center for Cellular Immunotherapies at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Cellular Immunotherapies at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Lim, Rebecca" sort="Lim, Rebecca" uniqKey="Lim R" first="Rebecca" last="Lim">Rebecca Lim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Obstetrics and Gynaecology, Hudson Institute of Medical Research, Monash University and The Ritchie Centre, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Obstetrics and Gynaecology, Hudson Institute of Medical Research, Monash University and The Ritchie Centre, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Lotvall, Jan" sort="Lotvall, Jan" uniqKey="Lotvall J" first="Jan" last="Lötvall">Jan Lötvall</name><affiliation wicri:level="1"><nlm:affiliation>Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Mitsialis, S Alex" sort="Mitsialis, S Alex" uniqKey="Mitsialis S" first="S Alex" last="Mitsialis">S Alex Mitsialis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Harvard Medical School and Boston Children's Hospital, Boston, Massachusetts, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Harvard Medical School and Boston Children's Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mongui Tortajada, Marta" sort="Mongui Tortajada, Marta" uniqKey="Mongui Tortajada M" first="Marta" last="Mongui Tortajada">Marta Mongui Tortajada</name><affiliation wicri:level="1"><nlm:affiliation>ICREC Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, and Cardiology Service, Germans Trias i Pujol University Hospital, Badalona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>ICREC Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, and Cardiology Service, Germans Trias i Pujol University Hospital, Badalona</wicri:regionArea><wicri:noRegion>Badalona</wicri:noRegion></affiliation></author><author><name sortKey="Muraca, Maurizio" sort="Muraca, Maurizio" uniqKey="Muraca M" first="Maurizio" last="Muraca">Maurizio Muraca</name><affiliation wicri:level="1"><nlm:affiliation>Department of Women's and Children's Health, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Women's and Children's Health, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Nieuwland, Rienk" sort="Nieuwland, Rienk" uniqKey="Nieuwland R" first="Rienk" last="Nieuwland">Rienk Nieuwland</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Experimental Clinical Chemistry, Department of Clinical Chemistry and Vesicle Observation Center, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Laboratory of Experimental Clinical Chemistry, Department of Clinical Chemistry and Vesicle Observation Center, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Nowocin, Anna" sort="Nowocin, Anna" uniqKey="Nowocin A" first="Anna" last="Nowocin">Anna Nowocin</name><affiliation wicri:level="1"><nlm:affiliation>Biotherapeutics, National Institute for Biological Standards and Control (NIBSC), Medicines and Healthcare Products Regulatory Agency, Hertfordshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Biotherapeutics, National Institute for Biological Standards and Control (NIBSC), Medicines and Healthcare Products Regulatory Agency, Hertfordshire</wicri:regionArea><wicri:noRegion>Hertfordshire</wicri:noRegion></affiliation></author><author><name sortKey="O Driscoll, Lorraine" sort="O Driscoll, Lorraine" uniqKey="O Driscoll L" first="Lorraine" last="O'Driscoll">Lorraine O'Driscoll</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Ortiz, Luis A" sort="Ortiz, Luis A" uniqKey="Ortiz L" first="Luis A" last="Ortiz">Luis A. Ortiz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Phinney, Donald G" sort="Phinney, Donald G" uniqKey="Phinney D" first="Donald G" last="Phinney">Donald G. Phinney</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Reischl, Ilona" sort="Reischl, Ilona" uniqKey="Reischl I" first="Ilona" last="Reischl">Ilona Reischl</name><affiliation wicri:level="3"><nlm:affiliation>Federal Office for Safety in Health Care (BASG) and Austrian Agency for Health and Food Safety (AGES), Institute Surveillance, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Federal Office for Safety in Health Care (BASG) and Austrian Agency for Health and Food Safety (AGES), Institute Surveillance, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Rohde, Eva" sort="Rohde, Eva" uniqKey="Rohde E" first="Eva" last="Rohde">Eva Rohde</name><affiliation wicri:level="1"><nlm:affiliation>Department of Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria; GMP Unit, Spinal Cord Injury & Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria; GMP Unit, Spinal Cord Injury & Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Sanzenbacher, Ralf" sort="Sanzenbacher, Ralf" uniqKey="Sanzenbacher R" first="Ralf" last="Sanzenbacher">Ralf Sanzenbacher</name><affiliation wicri:level="1"><nlm:affiliation>Section Tissue Engineering and Cell Therapeutics, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section Tissue Engineering and Cell Therapeutics, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen</wicri:regionArea><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion><wicri:noRegion>Langen</wicri:noRegion></affiliation></author><author><name sortKey="Thery, Clotilde" sort="Thery, Clotilde" uniqKey="Thery C" first="Clotilde" last="Théry">Clotilde Théry</name><affiliation wicri:level="3"><nlm:affiliation>Institut Curie/INSERM U932/PSL Research University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie/INSERM U932/PSL Research University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Toh, Wei Seong" sort="Toh, Wei Seong" uniqKey="Toh W" first="Wei Seong" last="Toh">Wei Seong Toh</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Dentistry, National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Faculty of Dentistry, National University of Singapore</wicri:regionArea><orgName type="university">Université nationale de Singapour</orgName></affiliation></author><author><name sortKey="Witwer, Kenneth W" sort="Witwer, Kenneth W" uniqKey="Witwer K" first="Kenneth W" last="Witwer">Kenneth W. Witwer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: kwitwer1@jhmi.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lim, Sai Kiang" sort="Lim, Sai Kiang" uniqKey="Lim S" first="Sai Kiang" last="Lim">Sai Kiang Lim</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore. Electronic address: Lim_Sai_Kiang@imcb.a-star.edu.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research</wicri:regionArea><wicri:noRegion>Technology and Research</wicri:noRegion></affiliation></author><author><name sortKey="Giebel, Bernd" sort="Giebel, Bernd" uniqKey="Giebel B" first="Bernd" last="Giebel">Bernd Giebel</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address: bernd.giebel@uk-essen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cytotherapy</title><idno type="eISSN">1477-2566</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (immunology)</term><term>Exosomes (transplantation)</term><term>Extracellular Vesicles (transplantation)</term><term>Humans (MeSH)</term><term>Mesenchymal Stem Cells (cytology)</term><term>Societies, Scientific (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules souches mésenchymateuses (cytologie)</term><term>Exosomes (transplantation)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Sociétés savantes (MeSH)</term><term>Vésicules extracellulaires (transplantation)</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches mésenchymateuses</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mesenchymal Stem Cells</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Exosomes</term><term>Extracellular Vesicles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Societies, Scientific</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="fr"><term>Exosomes</term><term>Humains</term><term>Sociétés savantes</term><term>Vésicules extracellulaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>STATEMENT</b></p><p>The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles (EVs, including exosomes) from mesenchymal stromal cells (MSCs) and possibly other cell sources as treatments for COVID-19. Research and trials in this area are encouraged. However, ISEV and ISCT do not currently endorse the use of EVs or exosomes for any purpose in COVID-19, including but not limited to reducing cytokine storm, exerting regenerative effects or delivering drugs, pending the generation of appropriate manufacturing and quality control provisions, pre-clinical safety and efficacy data, rational clinical trial design and proper regulatory oversight.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32425691</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1477-2566</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>09</Month></PubDate></JournalIssue><Title>Cytotherapy</Title><ISOAbbreviation>Cytotherapy</ISOAbbreviation></Journal><ArticleTitle>International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19.</ArticleTitle><Pagination><MedlinePgn>482-485</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1465-3249(20)30662-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcyt.2020.05.002</ELocationID><Abstract><AbstractText Label="STATEMENT">The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles (EVs, including exosomes) from mesenchymal stromal cells (MSCs) and possibly other cell sources as treatments for COVID-19. Research and trials in this area are encouraged. However, ISEV and ISCT do not currently endorse the use of EVs or exosomes for any purpose in COVID-19, including but not limited to reducing cytokine storm, exerting regenerative effects or delivering drugs, pending the generation of appropriate manufacturing and quality control provisions, pre-clinical safety and efficacy data, rational clinical trial design and proper regulatory oversight.</AbstractText><CopyrightInformation>Copyright © 2020 International Society for Cell and Gene Therapy. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Börger</LastName><ForeName>Verena</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiss</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Vermont, Burlington, Vermont, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Johnathon D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology, Stem Cell Program, University of California, Davis, Davis, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borràs</LastName><ForeName>Francesc E</ForeName><Initials>FE</Initials><AffiliationInfo><Affiliation>REMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, and Nephrology Service, Germans Trias i Pujol University Hospital, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bussolati</LastName><ForeName>Benedetta</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carter</LastName><ForeName>David R F</ForeName><Initials>DRF</Initials><AffiliationInfo><Affiliation>Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dominici</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Sciences of Children and Adults, University Hospital of Modena, Modena, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falcón-Pérez</LastName><ForeName>Juan M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Exosomes Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain; Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gimona</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>GMP Unit and EV-TT Transfer Center, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Andrew F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoffman</LastName><ForeName>Andrew M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Kleijn</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Vascular Surgery, University Medical Center Utrecht and Netherlands Heart Institute, Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levine</LastName><ForeName>Bruce L</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Center for Cellular Immunotherapies at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynaecology, Hudson Institute of Medical Research, Monash University and The Ritchie Centre, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lötvall</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitsialis</LastName><ForeName>S Alex</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Harvard Medical School and Boston Children's Hospital, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monguió-Tortajada</LastName><ForeName>Marta</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>ICREC Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, and Cardiology Service, Germans Trias i Pujol University Hospital, Badalona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muraca</LastName><ForeName>Maurizio</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Women's and Children's Health, University of Padua, Padua, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nieuwland</LastName><ForeName>Rienk</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Laboratory of Experimental Clinical Chemistry, Department of Clinical Chemistry and Vesicle Observation Center, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nowocin</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Biotherapeutics, National Institute for Biological Standards and Control (NIBSC), Medicines and Healthcare Products Regulatory Agency, Hertfordshire, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Driscoll</LastName><ForeName>Lorraine</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ortiz</LastName><ForeName>Luis A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phinney</LastName><ForeName>Donald G</ForeName><Initials>DG</Initials><AffiliationInfo><Affiliation>Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reischl</LastName><ForeName>Ilona</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Federal Office for Safety in Health Care (BASG) and Austrian Agency for Health and Food Safety (AGES), Institute Surveillance, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rohde</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria; GMP Unit, Spinal Cord Injury & Tissue Regeneration Centre Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanzenbacher</LastName><ForeName>Ralf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Section Tissue Engineering and Cell Therapeutics, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Théry</LastName><ForeName>Clotilde</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institut Curie/INSERM U932/PSL Research University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toh</LastName><ForeName>Wei Seong</ForeName><Initials>WS</Initials><AffiliationInfo><Affiliation>Faculty of Dentistry, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Witwer</LastName><ForeName>Kenneth W</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: kwitwer1@jhmi.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Sai Kiang</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore. Electronic address: Lim_Sai_Kiang@imcb.a-star.edu.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giebel</LastName><ForeName>Bernd</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Electronic address: bernd.giebel@uk-essen.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>KL2 TR001859</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 AR076861</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 HL086350</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR001860</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cytotherapy</MedlineTA><NlmUniqueID>100895309</NlmUniqueID><ISSNLinking>1465-3249</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055354" MajorTopicYN="N">Exosomes</DescriptorName><QualifierName UI="Q000637" MajorTopicYN="N">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000067128" MajorTopicYN="Y">Extracellular Vesicles</DescriptorName><QualifierName UI="Q000637" MajorTopicYN="N">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059630" MajorTopicYN="N">Mesenchymal Stem Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012958" MajorTopicYN="N">Societies, Scientific</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>05</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32425691</ArticleId><ArticleId IdType="doi">10.1016/j.jcyt.2020.05.002</ArticleId><ArticleId IdType="pii">S1465-3249(20)30662-9</ArticleId><ArticleId IdType="pmc">PMC7229942</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Espagne</li><li>France</li><li>Irlande (pays)</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Singapour</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Floride</li><li>Hollande-Septentrionale</li><li>Maryland</li><li>Massachusetts</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Piémont</li><li>Utrecht (province)</li><li>Vermont</li><li>Victoria (État)</li><li>Vienne (Autriche)</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Melbourne</li><li>Oxford</li><li>Paris</li><li>Pittsburgh</li><li>Turin</li><li>Utrecht</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université d'Amsterdam</li><li>Université de Pittsburgh</li><li>Université nationale de Singapour</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Borger, Verena" sort="Borger, Verena" uniqKey="Borger V" first="Verena" last="Börger">Verena Börger</name></noRegion><name sortKey="Giebel, Bernd" sort="Giebel, Bernd" uniqKey="Giebel B" first="Bernd" last="Giebel">Bernd Giebel</name><name sortKey="Sanzenbacher, Ralf" sort="Sanzenbacher, Ralf" uniqKey="Sanzenbacher R" first="Ralf" last="Sanzenbacher">Ralf Sanzenbacher</name></country><country name="États-Unis"><region name="Vermont"><name sortKey="Weiss, Daniel J" sort="Weiss, Daniel J" uniqKey="Weiss D" first="Daniel J" last="Weiss">Daniel J. Weiss</name></region><name sortKey="Anderson, Johnathon D" sort="Anderson, Johnathon D" uniqKey="Anderson J" first="Johnathon D" last="Anderson">Johnathon D. Anderson</name><name sortKey="Hoffman, Andrew M" sort="Hoffman, Andrew M" uniqKey="Hoffman A" first="Andrew M" last="Hoffman">Andrew M. Hoffman</name><name sortKey="Levine, Bruce L" sort="Levine, Bruce L" uniqKey="Levine B" first="Bruce L" last="Levine">Bruce L. Levine</name><name sortKey="Mitsialis, S Alex" sort="Mitsialis, S Alex" uniqKey="Mitsialis S" first="S Alex" last="Mitsialis">S Alex Mitsialis</name><name sortKey="Ortiz, Luis A" sort="Ortiz, Luis A" uniqKey="Ortiz L" first="Luis A" last="Ortiz">Luis A. Ortiz</name><name sortKey="Phinney, Donald G" sort="Phinney, Donald G" uniqKey="Phinney D" first="Donald G" last="Phinney">Donald G. Phinney</name><name sortKey="Witwer, Kenneth W" sort="Witwer, Kenneth W" uniqKey="Witwer K" first="Kenneth W" last="Witwer">Kenneth W. Witwer</name></country><country name="Espagne"><noRegion><name sortKey="Borras, Francesc E" sort="Borras, Francesc E" uniqKey="Borras F" first="Francesc E" last="Borràs">Francesc E. Borràs</name></noRegion><name sortKey="Falc N Perez, Juan M" sort="Falc N Perez, Juan M" uniqKey="Falc N Perez J" first="Juan M" last="Falc N-Pérez">Juan M. Falc N-Pérez</name><name sortKey="Mongui Tortajada, Marta" sort="Mongui Tortajada, Marta" uniqKey="Mongui Tortajada M" first="Marta" last="Mongui Tortajada">Marta Mongui Tortajada</name></country><country name="Italie"><region name="Piémont"><name sortKey="Bussolati, Benedetta" sort="Bussolati, Benedetta" uniqKey="Bussolati B" first="Benedetta" last="Bussolati">Benedetta Bussolati</name></region><name sortKey="Dominici, Massimo" sort="Dominici, Massimo" uniqKey="Dominici M" first="Massimo" last="Dominici">Massimo Dominici</name><name sortKey="Muraca, Maurizio" sort="Muraca, Maurizio" uniqKey="Muraca M" first="Maurizio" last="Muraca">Maurizio Muraca</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Carter, David R F" sort="Carter, David R F" uniqKey="Carter D" first="David R F" last="Carter">David R F. Carter</name></region><name sortKey="Nowocin, Anna" sort="Nowocin, Anna" uniqKey="Nowocin A" first="Anna" last="Nowocin">Anna Nowocin</name></country><country name="Autriche"><noRegion><name sortKey="Gimona, Mario" sort="Gimona, Mario" uniqKey="Gimona M" first="Mario" last="Gimona">Mario Gimona</name></noRegion><name sortKey="Reischl, Ilona" sort="Reischl, Ilona" uniqKey="Reischl I" first="Ilona" last="Reischl">Ilona Reischl</name><name sortKey="Rohde, Eva" sort="Rohde, Eva" uniqKey="Rohde E" first="Eva" last="Rohde">Eva Rohde</name></country><country name="Australie"><noRegion><name sortKey="Hill, Andrew F" sort="Hill, Andrew F" uniqKey="Hill A" first="Andrew F" last="Hill">Andrew F. Hill</name></noRegion><name sortKey="Lim, Rebecca" sort="Lim, Rebecca" uniqKey="Lim R" first="Rebecca" last="Lim">Rebecca Lim</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="De Kleijn, Dominique" sort="De Kleijn, Dominique" uniqKey="De Kleijn D" first="Dominique" last="De Kleijn">Dominique De Kleijn</name></region><name sortKey="Nieuwland, Rienk" sort="Nieuwland, Rienk" uniqKey="Nieuwland R" first="Rienk" last="Nieuwland">Rienk Nieuwland</name></country><country name="Suède"><noRegion><name sortKey="Lotvall, Jan" sort="Lotvall, Jan" uniqKey="Lotvall J" first="Jan" last="Lötvall">Jan Lötvall</name></noRegion></country><country name="Irlande (pays)"><noRegion><name sortKey="O Driscoll, Lorraine" sort="O Driscoll, Lorraine" uniqKey="O Driscoll L" first="Lorraine" last="O'Driscoll">Lorraine O'Driscoll</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Thery, Clotilde" sort="Thery, Clotilde" uniqKey="Thery C" first="Clotilde" last="Théry">Clotilde Théry</name></region></country><country name="Singapour"><noRegion><name sortKey="Toh, Wei Seong" sort="Toh, Wei Seong" uniqKey="Toh W" first="Wei Seong" last="Toh">Wei Seong Toh</name></noRegion><name sortKey="Lim, Sai Kiang" sort="Lim, Sai Kiang" uniqKey="Lim S" first="Sai Kiang" last="Lim">Sai Kiang Lim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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